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Telomere Length: Implications for Atherogenesis

PURPOSE OF REVIEW: The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease. RECENT FINDINGS: There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence data and capitalizing on genomic l...

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Autores principales: Yin, Hao, Pickering, J. Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947063/
https://www.ncbi.nlm.nih.gov/pubmed/36689071
http://dx.doi.org/10.1007/s11883-023-01082-6
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author Yin, Hao
Pickering, J. Geoffrey
author_facet Yin, Hao
Pickering, J. Geoffrey
author_sort Yin, Hao
collection PubMed
description PURPOSE OF REVIEW: The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease. RECENT FINDINGS: There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence data and capitalizing on genomic loci that associate with telomere length. These, together with more established approaches, have been used to generate a more complete picture of telomere length relationships with ischemic disease. Whereas earlier meta-analyses suggested an association between short leukocyte telomeres and ischemic disease, several recent large population studies now provide particularly compelling data, including an association with cardiovascular mortality. In addition, whether short leukocyte telomeres might be causally related to ischemic disease has been interrogated using Mendelian randomization strategies, which point to shorter leukocyte telomeres as a determining risk factor. Importantly however, the wide, interindividual variability in telomere length still means that a single assessment of leukocyte telomere length in an individual does not reliably report on a biological aging process. In this regard, recent multi-tissue analyses of telomere length dynamics are providing both new mechanistic insights into how telomere length and shortening rates may participate in atherogenesis and risk prediction opportunities. SUMMARY: The balance of evidence indicates that short leukocyte telomeres confer a risk for atherosclerotic cardiovascular disease. Moreover, an integrated analysis of telomere lengths in leukocytes and other tissues may provide a window into individualized telomere dynamics, raising new prospects for risk management.
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spelling pubmed-99470632023-02-24 Telomere Length: Implications for Atherogenesis Yin, Hao Pickering, J. Geoffrey Curr Atheroscler Rep Article PURPOSE OF REVIEW: The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease. RECENT FINDINGS: There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence data and capitalizing on genomic loci that associate with telomere length. These, together with more established approaches, have been used to generate a more complete picture of telomere length relationships with ischemic disease. Whereas earlier meta-analyses suggested an association between short leukocyte telomeres and ischemic disease, several recent large population studies now provide particularly compelling data, including an association with cardiovascular mortality. In addition, whether short leukocyte telomeres might be causally related to ischemic disease has been interrogated using Mendelian randomization strategies, which point to shorter leukocyte telomeres as a determining risk factor. Importantly however, the wide, interindividual variability in telomere length still means that a single assessment of leukocyte telomere length in an individual does not reliably report on a biological aging process. In this regard, recent multi-tissue analyses of telomere length dynamics are providing both new mechanistic insights into how telomere length and shortening rates may participate in atherogenesis and risk prediction opportunities. SUMMARY: The balance of evidence indicates that short leukocyte telomeres confer a risk for atherosclerotic cardiovascular disease. Moreover, an integrated analysis of telomere lengths in leukocytes and other tissues may provide a window into individualized telomere dynamics, raising new prospects for risk management. Springer US 2023-01-23 2023 /pmc/articles/PMC9947063/ /pubmed/36689071 http://dx.doi.org/10.1007/s11883-023-01082-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yin, Hao
Pickering, J. Geoffrey
Telomere Length: Implications for Atherogenesis
title Telomere Length: Implications for Atherogenesis
title_full Telomere Length: Implications for Atherogenesis
title_fullStr Telomere Length: Implications for Atherogenesis
title_full_unstemmed Telomere Length: Implications for Atherogenesis
title_short Telomere Length: Implications for Atherogenesis
title_sort telomere length: implications for atherogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947063/
https://www.ncbi.nlm.nih.gov/pubmed/36689071
http://dx.doi.org/10.1007/s11883-023-01082-6
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