TDP-43 Proteinopathy Specific Biomarker Development

TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer’s dementia. In such diseases, a biomarker that can...

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Autores principales: Cordts, Isabell, Wachinger, Annika, Scialo, Carlo, Lingor, Paul, Polymenidou, Magdalini, Buratti, Emanuele, Feneberg, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954136/
https://www.ncbi.nlm.nih.gov/pubmed/36831264
http://dx.doi.org/10.3390/cells12040597
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author Cordts, Isabell
Wachinger, Annika
Scialo, Carlo
Lingor, Paul
Polymenidou, Magdalini
Buratti, Emanuele
Feneberg, Emily
author_facet Cordts, Isabell
Wachinger, Annika
Scialo, Carlo
Lingor, Paul
Polymenidou, Magdalini
Buratti, Emanuele
Feneberg, Emily
author_sort Cordts, Isabell
collection PubMed
description TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer’s dementia. In such diseases, a biomarker that can detect TDP-43 proteinopathy in life would help to stratify patients according to their definite diagnosis of pathology, rather than in clinical subgroups of uncertain pathology. For therapies developed to target pathological proteins that cause the disease a biomarker to detect and track the underlying pathology would greatly enhance such undertakings. This article reviews the latest developments and outlooks of deriving TDP-43-specific biomarkers from the pathophysiological processes involved in the development of TDP-43 proteinopathy and studies using biosamples from clinical entities associated with TDP-43 pathology to investigate biomarker candidates.
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spelling pubmed-99541362023-02-25 TDP-43 Proteinopathy Specific Biomarker Development Cordts, Isabell Wachinger, Annika Scialo, Carlo Lingor, Paul Polymenidou, Magdalini Buratti, Emanuele Feneberg, Emily Cells Review TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer’s dementia. In such diseases, a biomarker that can detect TDP-43 proteinopathy in life would help to stratify patients according to their definite diagnosis of pathology, rather than in clinical subgroups of uncertain pathology. For therapies developed to target pathological proteins that cause the disease a biomarker to detect and track the underlying pathology would greatly enhance such undertakings. This article reviews the latest developments and outlooks of deriving TDP-43-specific biomarkers from the pathophysiological processes involved in the development of TDP-43 proteinopathy and studies using biosamples from clinical entities associated with TDP-43 pathology to investigate biomarker candidates. MDPI 2023-02-12 /pmc/articles/PMC9954136/ /pubmed/36831264 http://dx.doi.org/10.3390/cells12040597 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cordts, Isabell
Wachinger, Annika
Scialo, Carlo
Lingor, Paul
Polymenidou, Magdalini
Buratti, Emanuele
Feneberg, Emily
TDP-43 Proteinopathy Specific Biomarker Development
title TDP-43 Proteinopathy Specific Biomarker Development
title_full TDP-43 Proteinopathy Specific Biomarker Development
title_fullStr TDP-43 Proteinopathy Specific Biomarker Development
title_full_unstemmed TDP-43 Proteinopathy Specific Biomarker Development
title_short TDP-43 Proteinopathy Specific Biomarker Development
title_sort tdp-43 proteinopathy specific biomarker development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954136/
https://www.ncbi.nlm.nih.gov/pubmed/36831264
http://dx.doi.org/10.3390/cells12040597
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