TDP-43 Proteinopathy Specific Biomarker Development
TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer’s dementia. In such diseases, a biomarker that can...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954136/ https://www.ncbi.nlm.nih.gov/pubmed/36831264 http://dx.doi.org/10.3390/cells12040597 |
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author | Cordts, Isabell Wachinger, Annika Scialo, Carlo Lingor, Paul Polymenidou, Magdalini Buratti, Emanuele Feneberg, Emily |
author_facet | Cordts, Isabell Wachinger, Annika Scialo, Carlo Lingor, Paul Polymenidou, Magdalini Buratti, Emanuele Feneberg, Emily |
author_sort | Cordts, Isabell |
collection | PubMed |
description | TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer’s dementia. In such diseases, a biomarker that can detect TDP-43 proteinopathy in life would help to stratify patients according to their definite diagnosis of pathology, rather than in clinical subgroups of uncertain pathology. For therapies developed to target pathological proteins that cause the disease a biomarker to detect and track the underlying pathology would greatly enhance such undertakings. This article reviews the latest developments and outlooks of deriving TDP-43-specific biomarkers from the pathophysiological processes involved in the development of TDP-43 proteinopathy and studies using biosamples from clinical entities associated with TDP-43 pathology to investigate biomarker candidates. |
format | Online Article Text |
id | pubmed-9954136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99541362023-02-25 TDP-43 Proteinopathy Specific Biomarker Development Cordts, Isabell Wachinger, Annika Scialo, Carlo Lingor, Paul Polymenidou, Magdalini Buratti, Emanuele Feneberg, Emily Cells Review TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age-related TDP-43 encephalopathy, which clinically resembles Alzheimer’s dementia. In such diseases, a biomarker that can detect TDP-43 proteinopathy in life would help to stratify patients according to their definite diagnosis of pathology, rather than in clinical subgroups of uncertain pathology. For therapies developed to target pathological proteins that cause the disease a biomarker to detect and track the underlying pathology would greatly enhance such undertakings. This article reviews the latest developments and outlooks of deriving TDP-43-specific biomarkers from the pathophysiological processes involved in the development of TDP-43 proteinopathy and studies using biosamples from clinical entities associated with TDP-43 pathology to investigate biomarker candidates. MDPI 2023-02-12 /pmc/articles/PMC9954136/ /pubmed/36831264 http://dx.doi.org/10.3390/cells12040597 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cordts, Isabell Wachinger, Annika Scialo, Carlo Lingor, Paul Polymenidou, Magdalini Buratti, Emanuele Feneberg, Emily TDP-43 Proteinopathy Specific Biomarker Development |
title | TDP-43 Proteinopathy Specific Biomarker Development |
title_full | TDP-43 Proteinopathy Specific Biomarker Development |
title_fullStr | TDP-43 Proteinopathy Specific Biomarker Development |
title_full_unstemmed | TDP-43 Proteinopathy Specific Biomarker Development |
title_short | TDP-43 Proteinopathy Specific Biomarker Development |
title_sort | tdp-43 proteinopathy specific biomarker development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954136/ https://www.ncbi.nlm.nih.gov/pubmed/36831264 http://dx.doi.org/10.3390/cells12040597 |
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