Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization

Sphingosine‐1‐phosphate (S1P), the circulating HDL‐bound lipid mediator that acts via S1P receptors (S1PR), is required for normal vascular development. The role of this signaling axis in vascular retinopathies is unclear. Here, we show in a mouse model of oxygen‐induced retinopathy (OIR) that endot...

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Detalles Bibliográficos
Autores principales: Niaudet, Colin, Jung, Bongnam, Kuo, Andrew, Swendeman, Steven, Bull, Edward, Seno, Takahiro, Crocker, Reed, Fu, Zhongjie, Smith, Lois E H, Hla, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165359/
https://www.ncbi.nlm.nih.gov/pubmed/36912000
http://dx.doi.org/10.15252/emmm.202216645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165359/
https://www.ncbi.nlm.nih.gov/pubmed/36912000
http://dx.doi.org/10.15252/emmm.202216645

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