Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent RTA inhibitors. Among these, N-(pterin-7-carbonyl...

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Detalles Bibliográficos
Autores principales: Goto, Masaru, Sakamoto, Natsumi, Higashi, Shoko, Kawata, Rena, Nagatsu, Kazuki, Saito, Ryota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236969/
https://www.ncbi.nlm.nih.gov/pubmed/37259593
http://dx.doi.org/10.1080/14756366.2023.2219038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236969/
https://www.ncbi.nlm.nih.gov/pubmed/37259593
http://dx.doi.org/10.1080/14756366.2023.2219038

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