O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis
Diazo compounds are rare natural products possessing various biological activities. Kinamycin and lomaiviticin, two diazo natural products featured by the diazobenzofluorene core, exhibit exceptional potency as chemotherapeutic agents. Despite the extensive studies on their biosynthetic gene cluster...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477347/ https://www.ncbi.nlm.nih.gov/pubmed/37666836 http://dx.doi.org/10.1038/s41467-023-41062-7 |