Complement and its role in protection and pathogenesis of flavivirus infections

The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming...

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Detalles Bibliográficos
Autores principales: Avirutnan, Panisadee, Mehlhop, Erin, Diamond, Michael S.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768071/
https://www.ncbi.nlm.nih.gov/pubmed/19388173
http://dx.doi.org/10.1016/j.vaccine.2008.11.061
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author Avirutnan, Panisadee
Mehlhop, Erin
Diamond, Michael S.
author_facet Avirutnan, Panisadee
Mehlhop, Erin
Diamond, Michael S.
author_sort Avirutnan, Panisadee
collection PubMed
description The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.
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spelling pubmed-27680712009-12-30 Complement and its role in protection and pathogenesis of flavivirus infections Avirutnan, Panisadee Mehlhop, Erin Diamond, Michael S. Vaccine Article The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses. Elsevier Ltd. 2008-12-30 2008-12-23 /pmc/articles/PMC2768071/ /pubmed/19388173 http://dx.doi.org/10.1016/j.vaccine.2008.11.061 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Avirutnan, Panisadee
Mehlhop, Erin
Diamond, Michael S.
Complement and its role in protection and pathogenesis of flavivirus infections
title Complement and its role in protection and pathogenesis of flavivirus infections
title_full Complement and its role in protection and pathogenesis of flavivirus infections
title_fullStr Complement and its role in protection and pathogenesis of flavivirus infections
title_full_unstemmed Complement and its role in protection and pathogenesis of flavivirus infections
title_short Complement and its role in protection and pathogenesis of flavivirus infections
title_sort complement and its role in protection and pathogenesis of flavivirus infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768071/
https://www.ncbi.nlm.nih.gov/pubmed/19388173
http://dx.doi.org/10.1016/j.vaccine.2008.11.061
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