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Structural basis of receptor sharing by interleukin 17 cytokines

T helper type 17 (T(H)-17) cells, together with their effector cytokines including interleukin 17 (IL-17) family members, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a 1:2 complex of IL-17RA bound to IL-17F. The manner of c...

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Detalles Bibliográficos
Autores principales: Ely, Lauren K., Fischer, Suzanne, Garcia, K. Christopher
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783927/
https://www.ncbi.nlm.nih.gov/pubmed/19838198
http://dx.doi.org/10.1038/ni.1813
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author Ely, Lauren K.
Fischer, Suzanne
Garcia, K. Christopher
author_facet Ely, Lauren K.
Fischer, Suzanne
Garcia, K. Christopher
author_sort Ely, Lauren K.
collection PubMed
description T helper type 17 (T(H)-17) cells, together with their effector cytokines including interleukin 17 (IL-17) family members, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a 1:2 complex of IL-17RA bound to IL-17F. The manner of complex formation is unique for cytokines, and involves two fibronectin-type domains of IL-17RA engaging IL-17 within a groove between the IL-17 homodimer interface in a knob-and-hole fashion. The first receptor-binding event to the IL-17 cytokines modulates the affinity and specificity of the second receptor-binding event, thereby promoting heterodimeric versus homodimeric complex formation. IL-17RA utilizes a common recognition strategy to bind to several IL-17 family members, allowing it to potentially act as a shared receptor within multiple different signaling complexes.
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spelling pubmed-27839272010-06-01 Structural basis of receptor sharing by interleukin 17 cytokines Ely, Lauren K. Fischer, Suzanne Garcia, K. Christopher Nat Immunol Article T helper type 17 (T(H)-17) cells, together with their effector cytokines including interleukin 17 (IL-17) family members, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a 1:2 complex of IL-17RA bound to IL-17F. The manner of complex formation is unique for cytokines, and involves two fibronectin-type domains of IL-17RA engaging IL-17 within a groove between the IL-17 homodimer interface in a knob-and-hole fashion. The first receptor-binding event to the IL-17 cytokines modulates the affinity and specificity of the second receptor-binding event, thereby promoting heterodimeric versus homodimeric complex formation. IL-17RA utilizes a common recognition strategy to bind to several IL-17 family members, allowing it to potentially act as a shared receptor within multiple different signaling complexes. 2009-10-18 2009-12 /pmc/articles/PMC2783927/ /pubmed/19838198 http://dx.doi.org/10.1038/ni.1813 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ely, Lauren K.
Fischer, Suzanne
Garcia, K. Christopher
Structural basis of receptor sharing by interleukin 17 cytokines
title Structural basis of receptor sharing by interleukin 17 cytokines
title_full Structural basis of receptor sharing by interleukin 17 cytokines
title_fullStr Structural basis of receptor sharing by interleukin 17 cytokines
title_full_unstemmed Structural basis of receptor sharing by interleukin 17 cytokines
title_short Structural basis of receptor sharing by interleukin 17 cytokines
title_sort structural basis of receptor sharing by interleukin 17 cytokines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783927/
https://www.ncbi.nlm.nih.gov/pubmed/19838198
http://dx.doi.org/10.1038/ni.1813
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