Regulation of IL-9 expression by IL-25 signaling
The physiological regulation of interleukin 9 (IL-9) expression, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of TGF-β and interleukin 4 (IL-4) express high levels of interleukin 17 recepto...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827302/ https://www.ncbi.nlm.nih.gov/pubmed/20154671 http://dx.doi.org/10.1038/ni.1846 |
Sumario: | The physiological regulation of interleukin 9 (IL-9) expression, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of TGF-β and interleukin 4 (IL-4) express high levels of interleukin 17 receptor (IL-17R) B mRNA, the receptor for interleukin 25 (IL-25). Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral over-expression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression. |
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