Development of a less toxic dichloroacetate analogue by docking and descriptor analysis

Dichloroacetate (DCA) is a synthetic compound that promotes the activity of pyruvate dehydrogenase (PDH) by inhibiting its repressor protein called pyruvate dehydrogenase kinase (PDHK). The activation of PDH leads to a reduction in ambient cellular lactate concentrations both in vitro and in vivo wh...

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Detalles Bibliográficos
Autores principales: Subramanian, Kannan, Ramaian, Anand S
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039993/
https://www.ncbi.nlm.nih.gov/pubmed/21346867