Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

OBJECTIVE: Chronically elevated free fatty acids contribute to insulin resistance and pancreatic β-cell failure. Among numerous potential factors, the involvement of endoplasmic reticulum (ER) stress has been postulated to play a mechanistic role. Here we examined the efficacy of the chemical chaper...

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Detalles Bibliográficos
Autores principales: Xiao, Changting, Giacca, Adria, Lewis, Gary F.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046853/
https://www.ncbi.nlm.nih.gov/pubmed/21270237
http://dx.doi.org/10.2337/db10-1433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046853/
https://www.ncbi.nlm.nih.gov/pubmed/21270237
http://dx.doi.org/10.2337/db10-1433

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