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Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4

[Image: see text] Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs) and 13 of their tetrahydro-2-oxopyrimidin-1(2H)-yl analogues (PPB-SOs) were prepared and biologically evaluated. The antiproliferative activities of PIB-SOs on 16 cancer cell lines are in the nanomolar range and...

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Detalles Bibliográficos
Autores principales: Fortin, Sébastien, Wei, Lianhu, Moreau, Emmanuel, Lacroix, Jacques, Côté, Marie-France, Petitclerc, Éric, Kotra, Lakshmi P., C.-Gaudreault, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131785/
https://www.ncbi.nlm.nih.gov/pubmed/21604746
http://dx.doi.org/10.1021/jm200488a