The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

The NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is critical for host-defense, but ROS overproduction can also lead to inflammation and tissue injury. Here we report that TRPM2, a non-selective and redox-sensitive cation channel, inhibits ROS production in...

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Detalles Bibliográficos
Autores principales: Di, Anke, Gao, Xiao-Pei, Qian, Feng, Kawamura, Takeshi, Han, Jin, Hecquet, Claudie, Ye, Richard D., Vogel, Stephen M., Malik, Asrar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242890/
https://www.ncbi.nlm.nih.gov/pubmed/22101731
http://dx.doi.org/10.1038/ni.2171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242890/
https://www.ncbi.nlm.nih.gov/pubmed/22101731
http://dx.doi.org/10.1038/ni.2171

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