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SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Sinc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267776/ https://www.ncbi.nlm.nih.gov/pubmed/22168803 http://dx.doi.org/10.1186/1471-2407-11-518 |
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author | Neumann, Jens Bahr, Fiorina Horst, David Kriegl, Lydia Engel, Jutta Luque, Raquel Mejias Gerhard, Markus Kirchner, Thomas Jung, Andreas |
author_facet | Neumann, Jens Bahr, Fiorina Horst, David Kriegl, Lydia Engel, Jutta Luque, Raquel Mejias Gerhard, Markus Kirchner, Thomas Jung, Andreas |
author_sort | Neumann, Jens |
collection | PubMed |
description | BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. METHODS: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. RESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). CONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread. |
format | Online Article Text |
id | pubmed-3267776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32677762012-01-28 SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer Neumann, Jens Bahr, Fiorina Horst, David Kriegl, Lydia Engel, Jutta Luque, Raquel Mejias Gerhard, Markus Kirchner, Thomas Jung, Andreas BMC Cancer Research Article BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. METHODS: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. RESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). CONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread. BioMed Central 2011-12-14 /pmc/articles/PMC3267776/ /pubmed/22168803 http://dx.doi.org/10.1186/1471-2407-11-518 Text en Copyright ©2011 Neumann et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Neumann, Jens Bahr, Fiorina Horst, David Kriegl, Lydia Engel, Jutta Luque, Raquel Mejias Gerhard, Markus Kirchner, Thomas Jung, Andreas SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
title | SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
title_full | SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
title_fullStr | SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
title_full_unstemmed | SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
title_short | SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
title_sort | sox2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267776/ https://www.ncbi.nlm.nih.gov/pubmed/22168803 http://dx.doi.org/10.1186/1471-2407-11-518 |
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