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SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Sinc...

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Autores principales: Neumann, Jens, Bahr, Fiorina, Horst, David, Kriegl, Lydia, Engel, Jutta, Luque, Raquel Mejias, Gerhard, Markus, Kirchner, Thomas, Jung, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267776/
https://www.ncbi.nlm.nih.gov/pubmed/22168803
http://dx.doi.org/10.1186/1471-2407-11-518
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author Neumann, Jens
Bahr, Fiorina
Horst, David
Kriegl, Lydia
Engel, Jutta
Luque, Raquel Mejias
Gerhard, Markus
Kirchner, Thomas
Jung, Andreas
author_facet Neumann, Jens
Bahr, Fiorina
Horst, David
Kriegl, Lydia
Engel, Jutta
Luque, Raquel Mejias
Gerhard, Markus
Kirchner, Thomas
Jung, Andreas
author_sort Neumann, Jens
collection PubMed
description BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. METHODS: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. RESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). CONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread.
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spelling pubmed-32677762012-01-28 SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer Neumann, Jens Bahr, Fiorina Horst, David Kriegl, Lydia Engel, Jutta Luque, Raquel Mejias Gerhard, Markus Kirchner, Thomas Jung, Andreas BMC Cancer Research Article BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. METHODS: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. RESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). CONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread. BioMed Central 2011-12-14 /pmc/articles/PMC3267776/ /pubmed/22168803 http://dx.doi.org/10.1186/1471-2407-11-518 Text en Copyright ©2011 Neumann et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Neumann, Jens
Bahr, Fiorina
Horst, David
Kriegl, Lydia
Engel, Jutta
Luque, Raquel Mejias
Gerhard, Markus
Kirchner, Thomas
Jung, Andreas
SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
title SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
title_full SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
title_fullStr SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
title_full_unstemmed SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
title_short SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
title_sort sox2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267776/
https://www.ncbi.nlm.nih.gov/pubmed/22168803
http://dx.doi.org/10.1186/1471-2407-11-518
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