Down-Regulation of Yes Associated Protein 1 Expression Reduces Cell Proliferation and Clonogenicity of Pancreatic Cancer Cells

BACKGROUND: The Hippo pathway regulates organ size by inhibiting cell proliferation and promoting cell apoptosis upon its activation. The Yes Associated Protein 1 (YAP1) is a nuclear effector of the Hippo pathway that promotes cell growth as a transcription co-activator. In human cancer, the YAP1 ge...

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Detalles Bibliográficos
Autores principales: Diep, Caroline H., Zucker, Kelly M., Hostetter, Galen, Watanabe, Aprill, Hu, Chengcheng, Munoz, Ruben M., Von Hoff, Daniel D., Han, Haiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291657/
https://www.ncbi.nlm.nih.gov/pubmed/22396793
http://dx.doi.org/10.1371/journal.pone.0032783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291657/
https://www.ncbi.nlm.nih.gov/pubmed/22396793
http://dx.doi.org/10.1371/journal.pone.0032783

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