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Biological influence of Hakai in cancer: a 10-year review
In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in ep...
Autores principales: | Aparicio, Luis A., Valladares, Manuel, Blanco, Moisés, Alonso, Guillermo, Figueroa, Angélica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350634/ https://www.ncbi.nlm.nih.gov/pubmed/22349934 http://dx.doi.org/10.1007/s10555-012-9348-x |
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