A2A Adenosine Receptor Antagonism Enhances Synaptic and Motor Effects of Cocaine via CB1 Cannabinoid Receptor Activation

BACKGROUND: Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transporter. Endogenous DA modulates glutamatergic inputs to striatal neurons and this modulation influences motor activity. Since D2 DA and A2A-adenosine receptors (A2A-Rs) have antagonistic effec...

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Detalles Bibliográficos
Autores principales: Tozzi, Alessandro, de Iure, Antonio, Marsili, Valentina, Romano, Rosaria, Tantucci, Michela, Di Filippo, Massimiliano, Costa, Cinzia, Napolitano, Francesco, Mercuri, Nicola Biagio, Borsini, Franco, Giampà, Carmen, Fusco, Francesca Romana, Picconi, Barbara, Usiello, Alessandro, Calabresi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371006/
https://www.ncbi.nlm.nih.gov/pubmed/22715379
http://dx.doi.org/10.1371/journal.pone.0038312

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