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Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme
Biased codon usage in protein-coding genes is pervasive, whereby amino acids are largely encoded by a specific subset of possible codons. Within individual genes, codon bias is stronger at evolutionarily conserved residues, favoring codons recognized by abundant tRNAs. Although this observation sugg...
Autores principales: | Agashe, Deepa, Martinez-Gomez, N. Cecilia, Drummond, D. Allan, Marx, Christopher J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563975/ https://www.ncbi.nlm.nih.gov/pubmed/23223712 http://dx.doi.org/10.1093/molbev/mss273 |
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