Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species

OBJECTIVES: Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus, Aspergillus flavus, or Aspergillus niger is associated with high mortality. We evaluated the efficacy and compared the therapeutic effect differences of voriconazole (VRC) in combination with caspofungin (CAS) in tra...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ming, Su, Xin, Sun, Wen-Kui, Chen, Fei, Xu, Xiao-Yong, Shi, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915080/
https://www.ncbi.nlm.nih.gov/pubmed/24306184
http://dx.doi.org/10.1007/s11046-013-9719-z
_version_ 1782302520091082752
author Zhang, Ming
Su, Xin
Sun, Wen-Kui
Chen, Fei
Xu, Xiao-Yong
Shi, Yi
author_facet Zhang, Ming
Su, Xin
Sun, Wen-Kui
Chen, Fei
Xu, Xiao-Yong
Shi, Yi
author_sort Zhang, Ming
collection PubMed
description OBJECTIVES: Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus, Aspergillus flavus, or Aspergillus niger is associated with high mortality. We evaluated the efficacy and compared the therapeutic effect differences of voriconazole (VRC) in combination with caspofungin (CAS) in transiently neutropenic rats infected by A. fumigatus, A. flavus, or A. niger. METHODS: Treatment groups consisted of VRC (10 mg/kg q12 h) monotherapy, CAS (1 mg/kg/day) monotherapy, combination of VRC (10 mg/kg q12 h) + CAS (1 mg/kg/day), and no drug for 10 consecutive days. The efficacy and the difference in the treatments were evaluated through prolongation of survival, reduction in serum galactomannan levels and residual fungal burden, and histological studies. RESULTS: For all the strains, the combination of VRC and CAS led to significant prolongation in survival (P < 0.05) and reduction in residual fungal burden (P < 0.05) compared with CAS alone, and decrease in serum galactomannan levels (P < 0.05) compared with either agent alone. The survival in the combined therapy groups was significantly improved compared to VRC monotherapy for the strains of A. flavus and A. niger (P < 0.05), but no significant difference for the strains of A. fumigatus (P > 0.05). CONCLUSIONS: Combination of VRC and CAS was synergistic in IPA by A. flavus and A. niger, but small efficacy benefits in IPA by A. fumigatus.
format Online
Article
Text
id pubmed-3915080
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-39150802014-02-10 Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species Zhang, Ming Su, Xin Sun, Wen-Kui Chen, Fei Xu, Xiao-Yong Shi, Yi Mycopathologia Article OBJECTIVES: Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus, Aspergillus flavus, or Aspergillus niger is associated with high mortality. We evaluated the efficacy and compared the therapeutic effect differences of voriconazole (VRC) in combination with caspofungin (CAS) in transiently neutropenic rats infected by A. fumigatus, A. flavus, or A. niger. METHODS: Treatment groups consisted of VRC (10 mg/kg q12 h) monotherapy, CAS (1 mg/kg/day) monotherapy, combination of VRC (10 mg/kg q12 h) + CAS (1 mg/kg/day), and no drug for 10 consecutive days. The efficacy and the difference in the treatments were evaluated through prolongation of survival, reduction in serum galactomannan levels and residual fungal burden, and histological studies. RESULTS: For all the strains, the combination of VRC and CAS led to significant prolongation in survival (P < 0.05) and reduction in residual fungal burden (P < 0.05) compared with CAS alone, and decrease in serum galactomannan levels (P < 0.05) compared with either agent alone. The survival in the combined therapy groups was significantly improved compared to VRC monotherapy for the strains of A. flavus and A. niger (P < 0.05), but no significant difference for the strains of A. fumigatus (P > 0.05). CONCLUSIONS: Combination of VRC and CAS was synergistic in IPA by A. flavus and A. niger, but small efficacy benefits in IPA by A. fumigatus. Springer Netherlands 2013-12-06 2014 /pmc/articles/PMC3915080/ /pubmed/24306184 http://dx.doi.org/10.1007/s11046-013-9719-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Zhang, Ming
Su, Xin
Sun, Wen-Kui
Chen, Fei
Xu, Xiao-Yong
Shi, Yi
Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
title Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
title_full Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
title_fullStr Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
title_full_unstemmed Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
title_short Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
title_sort efficacy of the combination of voriconazole and caspofungin in experimental pulmonary aspergillosis by different aspergillus species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915080/
https://www.ncbi.nlm.nih.gov/pubmed/24306184
http://dx.doi.org/10.1007/s11046-013-9719-z
work_keys_str_mv AT zhangming efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies
AT suxin efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies
AT sunwenkui efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies
AT chenfei efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies
AT xuxiaoyong efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies
AT shiyi efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies