Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species
OBJECTIVES: Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus, Aspergillus flavus, or Aspergillus niger is associated with high mortality. We evaluated the efficacy and compared the therapeutic effect differences of voriconazole (VRC) in combination with caspofungin (CAS) in tra...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915080/ https://www.ncbi.nlm.nih.gov/pubmed/24306184 http://dx.doi.org/10.1007/s11046-013-9719-z |
_version_ | 1782302520091082752 |
---|---|
author | Zhang, Ming Su, Xin Sun, Wen-Kui Chen, Fei Xu, Xiao-Yong Shi, Yi |
author_facet | Zhang, Ming Su, Xin Sun, Wen-Kui Chen, Fei Xu, Xiao-Yong Shi, Yi |
author_sort | Zhang, Ming |
collection | PubMed |
description | OBJECTIVES: Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus, Aspergillus flavus, or Aspergillus niger is associated with high mortality. We evaluated the efficacy and compared the therapeutic effect differences of voriconazole (VRC) in combination with caspofungin (CAS) in transiently neutropenic rats infected by A. fumigatus, A. flavus, or A. niger. METHODS: Treatment groups consisted of VRC (10 mg/kg q12 h) monotherapy, CAS (1 mg/kg/day) monotherapy, combination of VRC (10 mg/kg q12 h) + CAS (1 mg/kg/day), and no drug for 10 consecutive days. The efficacy and the difference in the treatments were evaluated through prolongation of survival, reduction in serum galactomannan levels and residual fungal burden, and histological studies. RESULTS: For all the strains, the combination of VRC and CAS led to significant prolongation in survival (P < 0.05) and reduction in residual fungal burden (P < 0.05) compared with CAS alone, and decrease in serum galactomannan levels (P < 0.05) compared with either agent alone. The survival in the combined therapy groups was significantly improved compared to VRC monotherapy for the strains of A. flavus and A. niger (P < 0.05), but no significant difference for the strains of A. fumigatus (P > 0.05). CONCLUSIONS: Combination of VRC and CAS was synergistic in IPA by A. flavus and A. niger, but small efficacy benefits in IPA by A. fumigatus. |
format | Online Article Text |
id | pubmed-3915080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-39150802014-02-10 Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species Zhang, Ming Su, Xin Sun, Wen-Kui Chen, Fei Xu, Xiao-Yong Shi, Yi Mycopathologia Article OBJECTIVES: Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus, Aspergillus flavus, or Aspergillus niger is associated with high mortality. We evaluated the efficacy and compared the therapeutic effect differences of voriconazole (VRC) in combination with caspofungin (CAS) in transiently neutropenic rats infected by A. fumigatus, A. flavus, or A. niger. METHODS: Treatment groups consisted of VRC (10 mg/kg q12 h) monotherapy, CAS (1 mg/kg/day) monotherapy, combination of VRC (10 mg/kg q12 h) + CAS (1 mg/kg/day), and no drug for 10 consecutive days. The efficacy and the difference in the treatments were evaluated through prolongation of survival, reduction in serum galactomannan levels and residual fungal burden, and histological studies. RESULTS: For all the strains, the combination of VRC and CAS led to significant prolongation in survival (P < 0.05) and reduction in residual fungal burden (P < 0.05) compared with CAS alone, and decrease in serum galactomannan levels (P < 0.05) compared with either agent alone. The survival in the combined therapy groups was significantly improved compared to VRC monotherapy for the strains of A. flavus and A. niger (P < 0.05), but no significant difference for the strains of A. fumigatus (P > 0.05). CONCLUSIONS: Combination of VRC and CAS was synergistic in IPA by A. flavus and A. niger, but small efficacy benefits in IPA by A. fumigatus. Springer Netherlands 2013-12-06 2014 /pmc/articles/PMC3915080/ /pubmed/24306184 http://dx.doi.org/10.1007/s11046-013-9719-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Zhang, Ming Su, Xin Sun, Wen-Kui Chen, Fei Xu, Xiao-Yong Shi, Yi Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species |
title | Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species |
title_full | Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species |
title_fullStr | Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species |
title_full_unstemmed | Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species |
title_short | Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species |
title_sort | efficacy of the combination of voriconazole and caspofungin in experimental pulmonary aspergillosis by different aspergillus species |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915080/ https://www.ncbi.nlm.nih.gov/pubmed/24306184 http://dx.doi.org/10.1007/s11046-013-9719-z |
work_keys_str_mv | AT zhangming efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies AT suxin efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies AT sunwenkui efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies AT chenfei efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies AT xuxiaoyong efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies AT shiyi efficacyofthecombinationofvoriconazoleandcaspofungininexperimentalpulmonaryaspergillosisbydifferentaspergillusspecies |