Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
[Image: see text] The antimicrobial lipopeptides polymyxin B and E (colistin) are being used as a ‘last-line’ therapy for infections caused by multidrug-resistant Gram-negative pathogens. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections caused...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033650/ https://www.ncbi.nlm.nih.gov/pubmed/24601489 http://dx.doi.org/10.1021/cb500080r |
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author | Velkov, Tony Roberts, Kade D. Nation, Roger L. Wang, Jiping Thompson, Philip E. Li, Jian |
author_facet | Velkov, Tony Roberts, Kade D. Nation, Roger L. Wang, Jiping Thompson, Philip E. Li, Jian |
author_sort | Velkov, Tony |
collection | PubMed |
description | [Image: see text] The antimicrobial lipopeptides polymyxin B and E (colistin) are being used as a ‘last-line’ therapy for infections caused by multidrug-resistant Gram-negative pathogens. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections caused by the Gram-negative ‘superbugs’. This report details the structure–activity relationships (SAR) based design, in toto synthesis, and preclinical evaluation of a series of novel polymyxin lipopeptides with better antibacterial activity against polymyxin-resistant Gram-negative bacteria. |
format | Online Article Text |
id | pubmed-4033650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American
Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-40336502015-03-07 Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ Velkov, Tony Roberts, Kade D. Nation, Roger L. Wang, Jiping Thompson, Philip E. Li, Jian ACS Chem Biol [Image: see text] The antimicrobial lipopeptides polymyxin B and E (colistin) are being used as a ‘last-line’ therapy for infections caused by multidrug-resistant Gram-negative pathogens. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections caused by the Gram-negative ‘superbugs’. This report details the structure–activity relationships (SAR) based design, in toto synthesis, and preclinical evaluation of a series of novel polymyxin lipopeptides with better antibacterial activity against polymyxin-resistant Gram-negative bacteria. American Chemical Society 2014-03-07 2014-05-16 /pmc/articles/PMC4033650/ /pubmed/24601489 http://dx.doi.org/10.1021/cb500080r Text en Copyright © 2014 American Chemical Society |
spellingShingle | Velkov, Tony Roberts, Kade D. Nation, Roger L. Wang, Jiping Thompson, Philip E. Li, Jian Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ |
title | Teaching ‘Old’ Polymyxins New Tricks:
New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ |
title_full | Teaching ‘Old’ Polymyxins New Tricks:
New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ |
title_fullStr | Teaching ‘Old’ Polymyxins New Tricks:
New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ |
title_full_unstemmed | Teaching ‘Old’ Polymyxins New Tricks:
New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ |
title_short | Teaching ‘Old’ Polymyxins New Tricks:
New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ |
title_sort | teaching ‘old’ polymyxins new tricks:
new-generation lipopeptides targeting gram-negative ‘superbugs’ |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033650/ https://www.ncbi.nlm.nih.gov/pubmed/24601489 http://dx.doi.org/10.1021/cb500080r |
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