Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

[Image: see text] The antimicrobial lipopeptides polymyxin B and E (colistin) are being used as a ‘last-line’ therapy for infections caused by multidrug-resistant Gram-negative pathogens. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections caused...

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Autores principales: Velkov, Tony, Roberts, Kade D., Nation, Roger L., Wang, Jiping, Thompson, Philip E., Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033650/
https://www.ncbi.nlm.nih.gov/pubmed/24601489
http://dx.doi.org/10.1021/cb500080r
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author Velkov, Tony
Roberts, Kade D.
Nation, Roger L.
Wang, Jiping
Thompson, Philip E.
Li, Jian
author_facet Velkov, Tony
Roberts, Kade D.
Nation, Roger L.
Wang, Jiping
Thompson, Philip E.
Li, Jian
author_sort Velkov, Tony
collection PubMed
description [Image: see text] The antimicrobial lipopeptides polymyxin B and E (colistin) are being used as a ‘last-line’ therapy for infections caused by multidrug-resistant Gram-negative pathogens. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections caused by the Gram-negative ‘superbugs’. This report details the structure–activity relationships (SAR) based design, in toto synthesis, and preclinical evaluation of a series of novel polymyxin lipopeptides with better antibacterial activity against polymyxin-resistant Gram-negative bacteria.
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spelling pubmed-40336502015-03-07 Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’ Velkov, Tony Roberts, Kade D. Nation, Roger L. Wang, Jiping Thompson, Philip E. Li, Jian ACS Chem Biol [Image: see text] The antimicrobial lipopeptides polymyxin B and E (colistin) are being used as a ‘last-line’ therapy for infections caused by multidrug-resistant Gram-negative pathogens. Polymyxin resistance implies a total lack of antibiotics for the treatment of life-threatening infections caused by the Gram-negative ‘superbugs’. This report details the structure–activity relationships (SAR) based design, in toto synthesis, and preclinical evaluation of a series of novel polymyxin lipopeptides with better antibacterial activity against polymyxin-resistant Gram-negative bacteria. American Chemical Society 2014-03-07 2014-05-16 /pmc/articles/PMC4033650/ /pubmed/24601489 http://dx.doi.org/10.1021/cb500080r Text en Copyright © 2014 American Chemical Society
spellingShingle Velkov, Tony
Roberts, Kade D.
Nation, Roger L.
Wang, Jiping
Thompson, Philip E.
Li, Jian
Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
title Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
title_full Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
title_fullStr Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
title_full_unstemmed Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
title_short Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
title_sort teaching ‘old’ polymyxins new tricks: new-generation lipopeptides targeting gram-negative ‘superbugs’
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033650/
https://www.ncbi.nlm.nih.gov/pubmed/24601489
http://dx.doi.org/10.1021/cb500080r
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