A source of the single stranded DNA substrate for activation-induced deaminase during somatic hypermutation

During somatic hypermutation (SHM), activation-induced deaminase (AID) mutates deoxycytidine on single-stranded DNA (ssDNA) generated by the transcription machinery, but the detailed mechanism remains unclear. Here we report a higher abundance of RNA polymerase II (Pol II) at the immunoglobulin heav...

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Detalles Bibliográficos
Autores principales: Wang, Xiaohua, Fan, Manxia, Kalis, Susan, Wei, Lirong, Scharff, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154566/
https://www.ncbi.nlm.nih.gov/pubmed/24923561
http://dx.doi.org/10.1038/ncomms5137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154566/
https://www.ncbi.nlm.nih.gov/pubmed/24923561
http://dx.doi.org/10.1038/ncomms5137

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