Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

BACKGROUND: Previous Mendelian randomization studies have suggested that, while low-density lipoprotein cholesterol (LDL-c) and triglycerides are causally implicated in coronary artery disease (CAD) risk, high-density lipoprotein cholesterol (HDL-c) may not be, with causal effect estimates compatibl...

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Detalles Bibliográficos
Autores principales: Burgess, Stephen, Freitag, Daniel F., Khan, Hassan, Gorman, Donal N., Thompson, Simon G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193746/
https://www.ncbi.nlm.nih.gov/pubmed/25302496
http://dx.doi.org/10.1371/journal.pone.0108891