Coupled local translation and degradation regulate growth cone collapse

Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally synthesized, while most proteins are trafficked from the soma. The reason why only specific proteins are locally synthesized is unknown. Here we show...

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Detalles Bibliográficos
Autores principales: Deglincerti, Alessia, Colak, Dilek, Hengst, Ulrich, Liu, Yaobin, Xu, Guoqiang, Jaffrey, Samie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408908/
https://www.ncbi.nlm.nih.gov/pubmed/25901863
http://dx.doi.org/10.1038/ncomms7888