Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53
The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers. Here, we identify different classes of small molecules that bind to this crevice and determine their binding modes by X-ray crystallography. These...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671956/ https://www.ncbi.nlm.nih.gov/pubmed/26636255 http://dx.doi.org/10.1016/j.str.2015.10.016 |