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Toremifene interacts with and destabilizes the Ebola virus glycoprotein

Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no approved therapeutic drugs or vaccines for the disease. EBOV has a membrane envelope decorated by trimers of a glycoprotein (GP, cleaved by fu...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Ren, Jingshan, Harlos, Karl, Jones, Daniel M., Zeltina, Antra, Bowden, Thomas A., Padilla-Parra, Sergi, Fry, Elizabeth E., Stuart, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947387/
https://www.ncbi.nlm.nih.gov/pubmed/27362232
http://dx.doi.org/10.1038/nature18615