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Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data

Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use...

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Detalles Bibliográficos
Autores principales: Lee, Wei-Po, Yang, Kung-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054112/
https://www.ncbi.nlm.nih.gov/pubmed/18973867
http://dx.doi.org/10.1016/S1672-0229(08)60026-1
Descripción
Sumario:Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully.