Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis

Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malig...

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Autores principales: Balandrán, Juan Carlos, Purizaca, Jessica, Enciso, Jennifer, Dozal, David, Sandoval, Antonio, Jiménez-Hernández, Elva, Alemán-Lazarini, Leticia, Perez-Koldenkova, Vadim, Quintela-Núñez del Prado, Henry, Rios de los Ríos, Jussara, Mayani, Héctor, Ortiz-Navarrete, Vianney, Guzman, Monica L., Pelayo, Rosana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216624/
https://www.ncbi.nlm.nih.gov/pubmed/28111575
http://dx.doi.org/10.3389/fimmu.2016.00666
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author Balandrán, Juan Carlos
Purizaca, Jessica
Enciso, Jennifer
Dozal, David
Sandoval, Antonio
Jiménez-Hernández, Elva
Alemán-Lazarini, Leticia
Perez-Koldenkova, Vadim
Quintela-Núñez del Prado, Henry
Rios de los Ríos, Jussara
Mayani, Héctor
Ortiz-Navarrete, Vianney
Guzman, Monica L.
Pelayo, Rosana
author_facet Balandrán, Juan Carlos
Purizaca, Jessica
Enciso, Jennifer
Dozal, David
Sandoval, Antonio
Jiménez-Hernández, Elva
Alemán-Lazarini, Leticia
Perez-Koldenkova, Vadim
Quintela-Núñez del Prado, Henry
Rios de los Ríos, Jussara
Mayani, Héctor
Ortiz-Navarrete, Vianney
Guzman, Monica L.
Pelayo, Rosana
author_sort Balandrán, Juan Carlos
collection PubMed
description Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenvironmental signals that control early cell fate decisions are critical for tumor progression. We show here that the mesenchymal stromal cell component of ALL bone marrow (BM) differ from its normal counterpart in a number of functional properties and may have a key role during leukemic development. A decreased proliferation potential, contrasting with the strong ability of producing pro-inflammatory cytokines and an aberrantly loss of CXCL12 and SCF, suggest that leukemic lymphoid niches in ALL BM are unique and may exclude normal hematopoiesis. Cell competence ex vivo assays within tridimensional coculture structures indicated a growth advantage of leukemic precursor cells and their niche remodeling ability by CXCL12 reduction, resulting in leukemic cell progression at the expense of normal niche-associated lymphopoiesis.
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spelling pubmed-52166242017-01-20 Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis Balandrán, Juan Carlos Purizaca, Jessica Enciso, Jennifer Dozal, David Sandoval, Antonio Jiménez-Hernández, Elva Alemán-Lazarini, Leticia Perez-Koldenkova, Vadim Quintela-Núñez del Prado, Henry Rios de los Ríos, Jussara Mayani, Héctor Ortiz-Navarrete, Vianney Guzman, Monica L. Pelayo, Rosana Front Immunol Immunology Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenvironmental signals that control early cell fate decisions are critical for tumor progression. We show here that the mesenchymal stromal cell component of ALL bone marrow (BM) differ from its normal counterpart in a number of functional properties and may have a key role during leukemic development. A decreased proliferation potential, contrasting with the strong ability of producing pro-inflammatory cytokines and an aberrantly loss of CXCL12 and SCF, suggest that leukemic lymphoid niches in ALL BM are unique and may exclude normal hematopoiesis. Cell competence ex vivo assays within tridimensional coculture structures indicated a growth advantage of leukemic precursor cells and their niche remodeling ability by CXCL12 reduction, resulting in leukemic cell progression at the expense of normal niche-associated lymphopoiesis. Frontiers Media S.A. 2017-01-05 /pmc/articles/PMC5216624/ /pubmed/28111575 http://dx.doi.org/10.3389/fimmu.2016.00666 Text en Copyright © 2017 Balandrán, Purizaca, Enciso, Dozal, Sandoval, Jiménez-Hernández, Alemán-Lazarini, Perez-Koldenkova, Quintela-Núñez del Prado, Rios de los Ríos, Mayani, Ortiz-Navarrete, Guzman and Pelayo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Balandrán, Juan Carlos
Purizaca, Jessica
Enciso, Jennifer
Dozal, David
Sandoval, Antonio
Jiménez-Hernández, Elva
Alemán-Lazarini, Leticia
Perez-Koldenkova, Vadim
Quintela-Núñez del Prado, Henry
Rios de los Ríos, Jussara
Mayani, Héctor
Ortiz-Navarrete, Vianney
Guzman, Monica L.
Pelayo, Rosana
Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
title Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
title_full Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
title_fullStr Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
title_full_unstemmed Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
title_short Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
title_sort pro-inflammatory-related loss of cxcl12 niche promotes acute lymphoblastic leukemic progression at the expense of normal lymphopoiesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216624/
https://www.ncbi.nlm.nih.gov/pubmed/28111575
http://dx.doi.org/10.3389/fimmu.2016.00666
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