Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malig...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216624/ https://www.ncbi.nlm.nih.gov/pubmed/28111575 http://dx.doi.org/10.3389/fimmu.2016.00666 |
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author | Balandrán, Juan Carlos Purizaca, Jessica Enciso, Jennifer Dozal, David Sandoval, Antonio Jiménez-Hernández, Elva Alemán-Lazarini, Leticia Perez-Koldenkova, Vadim Quintela-Núñez del Prado, Henry Rios de los Ríos, Jussara Mayani, Héctor Ortiz-Navarrete, Vianney Guzman, Monica L. Pelayo, Rosana |
author_facet | Balandrán, Juan Carlos Purizaca, Jessica Enciso, Jennifer Dozal, David Sandoval, Antonio Jiménez-Hernández, Elva Alemán-Lazarini, Leticia Perez-Koldenkova, Vadim Quintela-Núñez del Prado, Henry Rios de los Ríos, Jussara Mayani, Héctor Ortiz-Navarrete, Vianney Guzman, Monica L. Pelayo, Rosana |
author_sort | Balandrán, Juan Carlos |
collection | PubMed |
description | Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenvironmental signals that control early cell fate decisions are critical for tumor progression. We show here that the mesenchymal stromal cell component of ALL bone marrow (BM) differ from its normal counterpart in a number of functional properties and may have a key role during leukemic development. A decreased proliferation potential, contrasting with the strong ability of producing pro-inflammatory cytokines and an aberrantly loss of CXCL12 and SCF, suggest that leukemic lymphoid niches in ALL BM are unique and may exclude normal hematopoiesis. Cell competence ex vivo assays within tridimensional coculture structures indicated a growth advantage of leukemic precursor cells and their niche remodeling ability by CXCL12 reduction, resulting in leukemic cell progression at the expense of normal niche-associated lymphopoiesis. |
format | Online Article Text |
id | pubmed-5216624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52166242017-01-20 Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis Balandrán, Juan Carlos Purizaca, Jessica Enciso, Jennifer Dozal, David Sandoval, Antonio Jiménez-Hernández, Elva Alemán-Lazarini, Leticia Perez-Koldenkova, Vadim Quintela-Núñez del Prado, Henry Rios de los Ríos, Jussara Mayani, Héctor Ortiz-Navarrete, Vianney Guzman, Monica L. Pelayo, Rosana Front Immunol Immunology Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenvironmental signals that control early cell fate decisions are critical for tumor progression. We show here that the mesenchymal stromal cell component of ALL bone marrow (BM) differ from its normal counterpart in a number of functional properties and may have a key role during leukemic development. A decreased proliferation potential, contrasting with the strong ability of producing pro-inflammatory cytokines and an aberrantly loss of CXCL12 and SCF, suggest that leukemic lymphoid niches in ALL BM are unique and may exclude normal hematopoiesis. Cell competence ex vivo assays within tridimensional coculture structures indicated a growth advantage of leukemic precursor cells and their niche remodeling ability by CXCL12 reduction, resulting in leukemic cell progression at the expense of normal niche-associated lymphopoiesis. Frontiers Media S.A. 2017-01-05 /pmc/articles/PMC5216624/ /pubmed/28111575 http://dx.doi.org/10.3389/fimmu.2016.00666 Text en Copyright © 2017 Balandrán, Purizaca, Enciso, Dozal, Sandoval, Jiménez-Hernández, Alemán-Lazarini, Perez-Koldenkova, Quintela-Núñez del Prado, Rios de los Ríos, Mayani, Ortiz-Navarrete, Guzman and Pelayo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Balandrán, Juan Carlos Purizaca, Jessica Enciso, Jennifer Dozal, David Sandoval, Antonio Jiménez-Hernández, Elva Alemán-Lazarini, Leticia Perez-Koldenkova, Vadim Quintela-Núñez del Prado, Henry Rios de los Ríos, Jussara Mayani, Héctor Ortiz-Navarrete, Vianney Guzman, Monica L. Pelayo, Rosana Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis |
title | Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis |
title_full | Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis |
title_fullStr | Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis |
title_full_unstemmed | Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis |
title_short | Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis |
title_sort | pro-inflammatory-related loss of cxcl12 niche promotes acute lymphoblastic leukemic progression at the expense of normal lymphopoiesis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216624/ https://www.ncbi.nlm.nih.gov/pubmed/28111575 http://dx.doi.org/10.3389/fimmu.2016.00666 |
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