A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers

Numerically the most important risk factor for the development of Parkinson's disease (PD) is the presence of mutations in the glucocerebrosidase GBA1 gene. In vitro and in vivo studies show that GBA1 mutations reduce glucocerebrosidase (GCase) activity and are associated with increased α-synuc...

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Detalles Bibliográficos
Autores principales: Yang, Shi-Yu, Beavan, Michelle, Chau, Kai-Yin, Taanman, Jan-Willem, Schapira, Anthony H.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355624/
https://www.ncbi.nlm.nih.gov/pubmed/28216145
http://dx.doi.org/10.1016/j.stemcr.2017.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355624/
https://www.ncbi.nlm.nih.gov/pubmed/28216145
http://dx.doi.org/10.1016/j.stemcr.2017.01.011

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