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Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data

Many genetic variants that influence phenotypes of interest are located outside of protein-coding genes, yet existing methods for identifying such variants have poor predictive power. Here, we introduce a new computational method, called LINSIGHT, that substantially improves the prediction of noncod...

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Detalles Bibliográficos
Autores principales: Huang, Yi-Fei, Gulko, Brad, Siepel, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395419/
https://www.ncbi.nlm.nih.gov/pubmed/28288115
http://dx.doi.org/10.1038/ng.3810