Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybrids

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, thereby evading the host's immune response. VSGs are monoallelically expressed from subtelomeric expression sites (ESs), and VSG switching exploits subtelomere plasticity. However, sub...

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Detalles Bibliográficos
Autores principales: Nanavaty, Vishal, Sandhu, Ranjodh, Jehi, Sanaa E., Pandya, Unnati M., Li, Bibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449629/
https://www.ncbi.nlm.nih.gov/pubmed/28334836
http://dx.doi.org/10.1093/nar/gkx184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449629/
https://www.ncbi.nlm.nih.gov/pubmed/28334836
http://dx.doi.org/10.1093/nar/gkx184

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