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Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain
Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546917/ https://www.ncbi.nlm.nih.gov/pubmed/28814877 http://dx.doi.org/10.2147/TCRM.S139814 |
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author | Shang, Xiushuai Wang, Zhaofei Tao, Hairong |
author_facet | Shang, Xiushuai Wang, Zhaofei Tao, Hairong |
author_sort | Shang, Xiushuai |
collection | PubMed |
description | Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. Since NGF blocking is an efficient way to inhibit OA-associated pain, we summarize four categories of drugs that target NGF/tropomyosin receptor kinase A (TrkA) signaling. In addition, we discuss the future of NGF/TrkA antagonists and underline their potential for use in OA pain relief. A better understanding of the causes and treatment of OA will facilitate the development of more effective methods of OA pain management. |
format | Online Article Text |
id | pubmed-5546917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55469172017-08-16 Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain Shang, Xiushuai Wang, Zhaofei Tao, Hairong Ther Clin Risk Manag Review Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. Since NGF blocking is an efficient way to inhibit OA-associated pain, we summarize four categories of drugs that target NGF/tropomyosin receptor kinase A (TrkA) signaling. In addition, we discuss the future of NGF/TrkA antagonists and underline their potential for use in OA pain relief. A better understanding of the causes and treatment of OA will facilitate the development of more effective methods of OA pain management. Dove Medical Press 2017-08-01 /pmc/articles/PMC5546917/ /pubmed/28814877 http://dx.doi.org/10.2147/TCRM.S139814 Text en © 2017 Shang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Shang, Xiushuai Wang, Zhaofei Tao, Hairong Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
title | Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
title_full | Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
title_fullStr | Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
title_full_unstemmed | Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
title_short | Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
title_sort | mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546917/ https://www.ncbi.nlm.nih.gov/pubmed/28814877 http://dx.doi.org/10.2147/TCRM.S139814 |
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