Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA

Multiple GWAS studies have reported strong association of cardiac QT-interval to a region on HSA17. Interestingly, a rat locus homologous to this region is also linked to QT-intervals. The high resolution positional mapping study located the rat QT-interval locus to a <42.5kb region on RNO10. Thi...

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Detalles Bibliográficos
Autores principales: Cheng, Xi, Waghulde, Harshal, Mell, Blair, Morgan, Eric E., Pruett-Miller, Shondra M., Joe, Bina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578691/
https://www.ncbi.nlm.nih.gov/pubmed/28827789
http://dx.doi.org/10.1371/journal.pgen.1006961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578691/
https://www.ncbi.nlm.nih.gov/pubmed/28827789
http://dx.doi.org/10.1371/journal.pgen.1006961

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