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Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease

Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish popul...

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Autores principales: Iwanicka, Joanna, Iwanicki, Tomasz, Niemiec, Paweł, Nowak, Tomasz, Krauze, Jolanta, Grzeszczak, Władysław, Górczyńska-Kosiorz, Sylwia, Ochalska-Tyka, Anna, Żak, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651137/
https://www.ncbi.nlm.nih.gov/pubmed/29118461
http://dx.doi.org/10.1155/2017/1540949
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author Iwanicka, Joanna
Iwanicki, Tomasz
Niemiec, Paweł
Nowak, Tomasz
Krauze, Jolanta
Grzeszczak, Władysław
Górczyńska-Kosiorz, Sylwia
Ochalska-Tyka, Anna
Żak, Iwona
author_facet Iwanicka, Joanna
Iwanicki, Tomasz
Niemiec, Paweł
Nowak, Tomasz
Krauze, Jolanta
Grzeszczak, Władysław
Górczyńska-Kosiorz, Sylwia
Ochalska-Tyka, Anna
Żak, Iwona
author_sort Iwanicka, Joanna
collection PubMed
description Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1.87, p = 0.041). The synergistic effect between the TT genotype and cigarette smoking was observed (SIM = 9.81; SI = 14.70). The relative increase in risk from interaction between factors was over 37 (RERI = 36.13). The PON1 polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population. Carriers of TT genotype seem to be particularly at risk of CAD, when exposed to cigarette smoking.
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spelling pubmed-56511372017-11-08 Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease Iwanicka, Joanna Iwanicki, Tomasz Niemiec, Paweł Nowak, Tomasz Krauze, Jolanta Grzeszczak, Władysław Górczyńska-Kosiorz, Sylwia Ochalska-Tyka, Anna Żak, Iwona Dis Markers Research Article Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the PON1 gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1.87, p = 0.041). The synergistic effect between the TT genotype and cigarette smoking was observed (SIM = 9.81; SI = 14.70). The relative increase in risk from interaction between factors was over 37 (RERI = 36.13). The PON1 polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population. Carriers of TT genotype seem to be particularly at risk of CAD, when exposed to cigarette smoking. Hindawi 2017 2017-09-29 /pmc/articles/PMC5651137/ /pubmed/29118461 http://dx.doi.org/10.1155/2017/1540949 Text en Copyright © 2017 Joanna Iwanicka et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Iwanicka, Joanna
Iwanicki, Tomasz
Niemiec, Paweł
Nowak, Tomasz
Krauze, Jolanta
Grzeszczak, Władysław
Górczyńska-Kosiorz, Sylwia
Ochalska-Tyka, Anna
Żak, Iwona
Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease
title Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease
title_full Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease
title_fullStr Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease
title_full_unstemmed Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease
title_short Relationship between rs854560 PON1 Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease
title_sort relationship between rs854560 pon1 gene polymorphism and tobacco smoking with coronary artery disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651137/
https://www.ncbi.nlm.nih.gov/pubmed/29118461
http://dx.doi.org/10.1155/2017/1540949
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