Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs

While the use of RNA interference (RNAi) in molecular biology and functional genomics is a well-established technology, in vivo applications of synthetic short interfering RNAs (siRNAs) require chemical modifications. We recently found that amides as non-ionic replacements for phosphodiesters may be...

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Detalles Bibliográficos
Autores principales: Mutisya, Daniel, Hardcastle, Travis, Cheruiyot, Samwel K., Pallan, Pradeep S., Kennedy, Scott D., Egli, Martin, Kelley, Melissa L., Smith, Anja van Brabant, Rozners, Eriks
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737567/
https://www.ncbi.nlm.nih.gov/pubmed/28854734
http://dx.doi.org/10.1093/nar/gkx558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737567/
https://www.ncbi.nlm.nih.gov/pubmed/28854734
http://dx.doi.org/10.1093/nar/gkx558

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