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Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstr...

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Autores principales: Grigura, Vadim, Barbier, Megan, Zarov, Anna P., Kaufman, Charles K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829507/
https://www.ncbi.nlm.nih.gov/pubmed/29362277
http://dx.doi.org/10.1242/bio.030726
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author Grigura, Vadim
Barbier, Megan
Zarov, Anna P.
Kaufman, Charles K.
author_facet Grigura, Vadim
Barbier, Megan
Zarov, Anna P.
Kaufman, Charles K.
author_sort Grigura, Vadim
collection PubMed
description The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.
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spelling pubmed-58295072018-02-28 Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model Grigura, Vadim Barbier, Megan Zarov, Anna P. Kaufman, Charles K. Biol Open Research Article The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model. The Company of Biologists Ltd 2018-01-15 /pmc/articles/PMC5829507/ /pubmed/29362277 http://dx.doi.org/10.1242/bio.030726 Text en © 2018. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Grigura, Vadim
Barbier, Megan
Zarov, Anna P.
Kaufman, Charles K.
Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_full Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_fullStr Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_full_unstemmed Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_short Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_sort feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829507/
https://www.ncbi.nlm.nih.gov/pubmed/29362277
http://dx.doi.org/10.1242/bio.030726
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