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Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829507/ https://www.ncbi.nlm.nih.gov/pubmed/29362277 http://dx.doi.org/10.1242/bio.030726 |
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author | Grigura, Vadim Barbier, Megan Zarov, Anna P. Kaufman, Charles K. |
author_facet | Grigura, Vadim Barbier, Megan Zarov, Anna P. Kaufman, Charles K. |
author_sort | Grigura, Vadim |
collection | PubMed |
description | The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model. |
format | Online Article Text |
id | pubmed-5829507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58295072018-02-28 Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model Grigura, Vadim Barbier, Megan Zarov, Anna P. Kaufman, Charles K. Biol Open Research Article The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model. The Company of Biologists Ltd 2018-01-15 /pmc/articles/PMC5829507/ /pubmed/29362277 http://dx.doi.org/10.1242/bio.030726 Text en © 2018. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Grigura, Vadim Barbier, Megan Zarov, Anna P. Kaufman, Charles K. Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
title | Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
title_full | Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
title_fullStr | Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
title_full_unstemmed | Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
title_short | Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
title_sort | feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829507/ https://www.ncbi.nlm.nih.gov/pubmed/29362277 http://dx.doi.org/10.1242/bio.030726 |
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