DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?
Although our knowledge of chromatin organization has advanced significantly in recent years, much about the relationships between different features of genome architecture is still unknown. Folding of mammalian genomes into spatial domains is thought to depend on architectural proteins, other DNA-bi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877745/ https://www.ncbi.nlm.nih.gov/pubmed/29547555 http://dx.doi.org/10.3390/ijms19030884 |
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author | Björkegren, Camilla Baranello, Laura |
author_facet | Björkegren, Camilla Baranello, Laura |
author_sort | Björkegren, Camilla |
collection | PubMed |
description | Although our knowledge of chromatin organization has advanced significantly in recent years, much about the relationships between different features of genome architecture is still unknown. Folding of mammalian genomes into spatial domains is thought to depend on architectural proteins, other DNA-binding proteins, and different forms of RNA. In addition, emerging evidence points towards the possibility that the three-dimensional organisation of the genome is controlled by DNA topology. In this scenario, cohesin, CCCTC-binding factor (CTCF), transcription, DNA supercoiling, and topoisomerases are integrated to dictate different layers of genome organization, and the contribution of all four to gene control is an important direction of future studies. In this perspective, we review recent studies that give new insight on how DNA supercoiling shape chromatin structure. |
format | Online Article Text |
id | pubmed-5877745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58777452018-04-09 DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? Björkegren, Camilla Baranello, Laura Int J Mol Sci Opinion Although our knowledge of chromatin organization has advanced significantly in recent years, much about the relationships between different features of genome architecture is still unknown. Folding of mammalian genomes into spatial domains is thought to depend on architectural proteins, other DNA-binding proteins, and different forms of RNA. In addition, emerging evidence points towards the possibility that the three-dimensional organisation of the genome is controlled by DNA topology. In this scenario, cohesin, CCCTC-binding factor (CTCF), transcription, DNA supercoiling, and topoisomerases are integrated to dictate different layers of genome organization, and the contribution of all four to gene control is an important direction of future studies. In this perspective, we review recent studies that give new insight on how DNA supercoiling shape chromatin structure. MDPI 2018-03-16 /pmc/articles/PMC5877745/ /pubmed/29547555 http://dx.doi.org/10.3390/ijms19030884 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Björkegren, Camilla Baranello, Laura DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? |
title | DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? |
title_full | DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? |
title_fullStr | DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? |
title_full_unstemmed | DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? |
title_short | DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? |
title_sort | dna supercoiling, topoisomerases, and cohesin: partners in regulating chromatin architecture? |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877745/ https://www.ncbi.nlm.nih.gov/pubmed/29547555 http://dx.doi.org/10.3390/ijms19030884 |
work_keys_str_mv | AT bjorkegrencamilla dnasupercoilingtopoisomerasesandcohesinpartnersinregulatingchromatinarchitecture AT baranellolaura dnasupercoilingtopoisomerasesandcohesinpartnersinregulatingchromatinarchitecture |