Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy

The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent antibacterial properties that was engineered to overcome efflux liability. Compounds liable to efflux specificall...

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Detalles Bibliográficos
Autores principales: Hameed P, Shahul, Bharatham, Nagakumar, Katagihallimath, Nainesh, Sharma, Sreevalli, Nandishaiah, Radha, Shanbhag, Anirudh P., Thomas, Teby, Narjari, Riya, Sarma, Maitrayee, Bhowmik, Purnendu, Amar, Prakruthi, Ravishankar, Rajani, Jayaraman, Ramesh, Muthan, Kubendran, Subbiah, Ramesh, Ramachandran, Vasanthi, Balasubramanian, V., Datta, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940854/
https://www.ncbi.nlm.nih.gov/pubmed/29740005
http://dx.doi.org/10.1038/s41598-018-25407-7

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