Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium

We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately seven active stem cells residing within each colonic crypt has to be muta...

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Detalles Bibliográficos
Autores principales: Nicholson, Anna M., Olpe, Cora, Hoyle, Alice, Thorsen, Ann-Sofie, Rus, Teja, Colombé, Mathilde, Brunton-Sim, Roxanne, Kemp, Richard, Marks, Kate, Quirke, Phil, Malhotra, Shalini, ten Hoopen, Rogier, Ibrahim, Ashraf, Lindskog, Cecilia, Myers, Meagan B., Parsons, Barbara, Tavaré, Simon, Wilkinson, Mark, Morrissey, Edward, Winton, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989058/
https://www.ncbi.nlm.nih.gov/pubmed/29779891
http://dx.doi.org/10.1016/j.stem.2018.04.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989058/
https://www.ncbi.nlm.nih.gov/pubmed/29779891
http://dx.doi.org/10.1016/j.stem.2018.04.020

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