Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent dr...

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Detalles Bibliográficos
Autores principales: Gabriele, Elena, Ricci, Chiara, Meneghetti, Fiorella, Ferri, Nicola, Asai, Akira, Sparatore, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009886/
https://www.ncbi.nlm.nih.gov/pubmed/28097912
http://dx.doi.org/10.1080/14756366.2016.1252757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009886/
https://www.ncbi.nlm.nih.gov/pubmed/28097912
http://dx.doi.org/10.1080/14756366.2016.1252757

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