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Allostery and cooperativity in multimeric proteins: bond-to-bond propensities in ATCase
Aspartate carbamoyltransferase (ATCase) is a large dodecameric enzyme with six active sites that exhibits allostery: its catalytic rate is modulated by the binding of various substrates at distal points from the active sites. A recently developed method, bond-to-bond propensity analysis, has proven...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056424/ https://www.ncbi.nlm.nih.gov/pubmed/30038211 http://dx.doi.org/10.1038/s41598-018-27992-z |