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A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade
Evidence from mouse chronic viral infection models suggests that CD8(+) T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110381/ https://www.ncbi.nlm.nih.gov/pubmed/29892065 http://dx.doi.org/10.1038/s41591-018-0057-z |
Sumario: | Evidence from mouse chronic viral infection models suggests that CD8(+) T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels. We compared transcriptional, metabolic, and functional signatures of intratumoral CD8(+) T lymphocyte populations with high (PD-1(T)), intermediate (PD-1(N)) and no PD-1 expression (PD-1(-)) from non-small cell lung cancer patients. We observed that, PD-1(T) T cells show a markedly different transcriptional and metabolic profile as compared to PD-1(N) and PD-1(-) lymphocytes, as well as an intrinsically high capacity for tumor recognition. Furthermore, while PD-1(T) lymphocytes are impaired in classical effector cytokine production, they produce CXCL13 that mediates immune cell recruitment to tertiary lymphoid structures. Strikingly, the presence of PD-1(T) cells was strongly predictive for both response and survival in a small cohort of non-small cell lung cancer patients treated with PD-1 blockade. The characterization of a distinct state of tumor-reactive, PD-1 bright lymphocytes in human cancer, which only partially resembles that seen in chronic infection, provides novel potential avenues for therapeutic intervention. |
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