Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation

Self‐renewal of embryonic stem cells (ESCs) cultured in LIF/fetal calf serum (FCS) is incomplete with some cells initiating differentiation. While this is reflected in heterogeneous expression of naive pluripotency transcription factors (TFs), the link between TF heterogeneity and differentiation is...

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Detalles Bibliográficos
Autores principales: Festuccia, Nicola, Halbritter, Florian, Corsinotti, Andrea, Gagliardi, Alessia, Colby, Douglas, Tomlinson, Simon R, Chambers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213284/
https://www.ncbi.nlm.nih.gov/pubmed/30275266
http://dx.doi.org/10.15252/embj.201695476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213284/
https://www.ncbi.nlm.nih.gov/pubmed/30275266
http://dx.doi.org/10.15252/embj.201695476

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