A dynamic N(6)-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors
N(6)-methyladenosine (m(6)A) on mRNAs is critical for various biological processes, yet whether m(6)A regulates drug resistance remains unknown. Here we show that developing resistant phenotypes during tyrosine kinase inhibitor (TKI) therapy depends on m(6)A reduction resulting from FTO overexpressi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218444/ https://www.ncbi.nlm.nih.gov/pubmed/30297871 http://dx.doi.org/10.1038/s41422-018-0097-4 |