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Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus

Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to ca...

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Autores principales: Bukhari, Shazia Anwer, Shamshari, Waseem Akhtar, Mahmood-Ur-Rahman, Zia-Ul-Haq, Muhammad, Jaafar, Hawa Z. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271604/
https://www.ncbi.nlm.nih.gov/pubmed/25019556
http://dx.doi.org/10.3390/molecules190710129
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author Bukhari, Shazia Anwer
Shamshari, Waseem Akhtar
Mahmood-Ur-Rahman,
Zia-Ul-Haq, Muhammad
Jaafar, Hawa Z. E.
author_facet Bukhari, Shazia Anwer
Shamshari, Waseem Akhtar
Mahmood-Ur-Rahman,
Zia-Ul-Haq, Muhammad
Jaafar, Hawa Z. E.
author_sort Bukhari, Shazia Anwer
collection PubMed
description Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to cause five times more risk of diabetes when expressed above average levels. This study was therefore designed to analyze the SFRP4 and to find its potential inhibitors. SFRP4 was analyzed by bio-informatics tools of sequence tool and structure tool. A total of three potential inhibitors of SFRP4 were found, namely cyclothiazide, clopamide and perindopril. These inhibitors showed significant interactions with SFRP4 as compared to other inhibitors as well as control (acetohexamide). The findings suggest the possible treatment of diabetes mellitus type 2 by inhibiting the SFRP4 using the inhibitors cyclothiazide, clopamide and perindopril.
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spelling pubmed-62716042018-12-21 Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus Bukhari, Shazia Anwer Shamshari, Waseem Akhtar Mahmood-Ur-Rahman, Zia-Ul-Haq, Muhammad Jaafar, Hawa Z. E. Molecules Article Diabetes mellitus is a life threatening disease and scientists are doing their best to find a cost effective and permanent treatment of this malady. The recent trend is to control the disease by target base inhibiting of enzymes or proteins. Secreted frizzled-related protein 4 (SFRP4) is found to cause five times more risk of diabetes when expressed above average levels. This study was therefore designed to analyze the SFRP4 and to find its potential inhibitors. SFRP4 was analyzed by bio-informatics tools of sequence tool and structure tool. A total of three potential inhibitors of SFRP4 were found, namely cyclothiazide, clopamide and perindopril. These inhibitors showed significant interactions with SFRP4 as compared to other inhibitors as well as control (acetohexamide). The findings suggest the possible treatment of diabetes mellitus type 2 by inhibiting the SFRP4 using the inhibitors cyclothiazide, clopamide and perindopril. MDPI 2014-07-11 /pmc/articles/PMC6271604/ /pubmed/25019556 http://dx.doi.org/10.3390/molecules190710129 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bukhari, Shazia Anwer
Shamshari, Waseem Akhtar
Mahmood-Ur-Rahman,
Zia-Ul-Haq, Muhammad
Jaafar, Hawa Z. E.
Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus
title Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus
title_full Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus
title_fullStr Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus
title_full_unstemmed Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus
title_short Computer Aided Screening of Secreted Frizzled-Related Protein 4 (SFRP4): A Potential Control for Diabetes Mellitus
title_sort computer aided screening of secreted frizzled-related protein 4 (sfrp4): a potential control for diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271604/
https://www.ncbi.nlm.nih.gov/pubmed/25019556
http://dx.doi.org/10.3390/molecules190710129
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