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The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug developme...

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Detalles Bibliográficos
Autores principales: Jornada, Daniela Hartmann, dos Santos Fernandes, Guilherme Felipe, Chiba, Diego Eidy, de Melo, Thais Regina Ferreira, dos Santos, Jean Leandro, Chung, Man Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273601/
https://www.ncbi.nlm.nih.gov/pubmed/26729077
http://dx.doi.org/10.3390/molecules21010042
Descripción
Sumario:Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.