Detection of persistent signals and its relation to coherent feed-forward loops

Many studies have shown that cells use the temporal dynamics of signalling molecules to encode information. One particular class of temporal dynamics is persistent and transient signals, i.e. signals of long and short duration, respectively. It has been shown that the coherent type-1 feed-forward lo...

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Autor principal: Chou, Chun Tung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281907/
https://www.ncbi.nlm.nih.gov/pubmed/30564429
http://dx.doi.org/10.1098/rsos.181641
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author Chou, Chun Tung
author_facet Chou, Chun Tung
author_sort Chou, Chun Tung
collection PubMed
description Many studies have shown that cells use the temporal dynamics of signalling molecules to encode information. One particular class of temporal dynamics is persistent and transient signals, i.e. signals of long and short duration, respectively. It has been shown that the coherent type-1 feed-forward loop with an AND logic at the output (or C1-FFL for short) can be used to discriminate a persistent input signal from a transient one. This has been done by modelling the C1-FFL, and then using the model to show that persistent and transient input signals give, respectively, a non-zero and zero output. The aim of this paper is to make a connection between the statistical detection of persistent signals and the C1-FFL. We begin by first formulating a statistical detection problem of distinguishing persistent signals from transient ones. The solution of the detection problem is to compute the log-likelihood ratio of observing a persistent signal to a transient signal. We show that, if this log-likelihood ratio is positive, which happens when the signal is likely to be persistent, then it can be approximately computed by a C1-FFL. Although the capability of C1-FFL to discriminate persistent signals is known, this paper adds an information processing interpretation on how a C1-FFL works as a detector of persistent signals.
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spelling pubmed-62819072018-12-18 Detection of persistent signals and its relation to coherent feed-forward loops Chou, Chun Tung R Soc Open Sci Biochemistry and Biophysics Many studies have shown that cells use the temporal dynamics of signalling molecules to encode information. One particular class of temporal dynamics is persistent and transient signals, i.e. signals of long and short duration, respectively. It has been shown that the coherent type-1 feed-forward loop with an AND logic at the output (or C1-FFL for short) can be used to discriminate a persistent input signal from a transient one. This has been done by modelling the C1-FFL, and then using the model to show that persistent and transient input signals give, respectively, a non-zero and zero output. The aim of this paper is to make a connection between the statistical detection of persistent signals and the C1-FFL. We begin by first formulating a statistical detection problem of distinguishing persistent signals from transient ones. The solution of the detection problem is to compute the log-likelihood ratio of observing a persistent signal to a transient signal. We show that, if this log-likelihood ratio is positive, which happens when the signal is likely to be persistent, then it can be approximately computed by a C1-FFL. Although the capability of C1-FFL to discriminate persistent signals is known, this paper adds an information processing interpretation on how a C1-FFL works as a detector of persistent signals. The Royal Society 2018-11-07 /pmc/articles/PMC6281907/ /pubmed/30564429 http://dx.doi.org/10.1098/rsos.181641 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Biochemistry and Biophysics
Chou, Chun Tung
Detection of persistent signals and its relation to coherent feed-forward loops
title Detection of persistent signals and its relation to coherent feed-forward loops
title_full Detection of persistent signals and its relation to coherent feed-forward loops
title_fullStr Detection of persistent signals and its relation to coherent feed-forward loops
title_full_unstemmed Detection of persistent signals and its relation to coherent feed-forward loops
title_short Detection of persistent signals and its relation to coherent feed-forward loops
title_sort detection of persistent signals and its relation to coherent feed-forward loops
topic Biochemistry and Biophysics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281907/
https://www.ncbi.nlm.nih.gov/pubmed/30564429
http://dx.doi.org/10.1098/rsos.181641
work_keys_str_mv AT chouchuntung detectionofpersistentsignalsanditsrelationtocoherentfeedforwardloops