Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats
BACKGROUND/OBJECTIVES: Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocyte-secreted hormone that is important for controlling body w...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423225/ https://www.ncbi.nlm.nih.gov/pubmed/30886140 http://dx.doi.org/10.1038/s41387-019-0076-y |