PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells

The PIM1, PIM2, and PIM3 serine/threonine kinases play a role in the proliferation and survival of cancer cells. Mice lacking these three kinases were viable. Further, in human hematological malignancies, these proteins are overexpressed making them suitable targets. Several small molecule inhibitor...

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Detalles Bibliográficos
Autores principales: Cervantes-Gomez, Fabiola, Stellrecht, Christine M., Ayres, Mary L., Keating, Michael J., Wierda, William G., Gandhi, Varsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497463/
https://www.ncbi.nlm.nih.gov/pubmed/31073371
http://dx.doi.org/10.18632/oncotarget.26876