The rs17084733 variant in the KIT 3’ UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility

Several miRNAs are dysregulated in gastrointestinal stromal tumours (GIST), and miR-221/222 appear to have a prominent role in GIST biology. Therefore, we investigated the role of DNA variants located in miR-221/222 precursor sequences and their target KIT 3'UTR. Ninety-five polymorphisms were...

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Detalles Bibliográficos
Autores principales: Ravegnini, Gloria, Serrano, César, Simeon, Vittorio, Sammarini, Giulia, Nannini, Margherita, Roversi, Erica, Urbini, Milena, Ferrè, Fabrizio, Ricci, Riccardo, Tarantino, Giuseppe, Pantaleo, Maria A., Hrelia, Patrizia, Angelini, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557610/
https://www.ncbi.nlm.nih.gov/pubmed/30983504
http://dx.doi.org/10.1080/15592294.2019.1595997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557610/
https://www.ncbi.nlm.nih.gov/pubmed/30983504
http://dx.doi.org/10.1080/15592294.2019.1595997

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