An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing

Adenine N6 methylation in DNA (6mA) is widespread among bacteria and phage and is detected in mammalian genomes, where its function is largely unexplored. Here we show that 6mA deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA acc...

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Detalles Bibliográficos
Autores principales: Kweon, Soo-Mi, Chen, Yibu, Moon, Eugene, Kvederaviciutė, Kotryna, Klimasauskas, Saulius, Feldman, Douglas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591016/
https://www.ncbi.nlm.nih.gov/pubmed/30982744
http://dx.doi.org/10.1016/j.molcel.2019.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591016/
https://www.ncbi.nlm.nih.gov/pubmed/30982744
http://dx.doi.org/10.1016/j.molcel.2019.03.018

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