Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism

BACKGROUND: Alzheimer’s disease (AD) is a neuropathology strongly associated with the activation of inflammatory pathways. Accordingly, inflammation resulting from obesity exacerbates learning and memory deficits in humans and in animal models of AD. Consequently, the long-term use of non-steroidal...

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Detalles Bibliográficos
Autores principales: Medrano-Jiménez, Elisa, Jiménez-Ferrer Carrillo, Itzia, Pedraza-Escalona, Martha, Ramírez-Serrano, Cristina E., Álvarez-Arellano, Lourdes, Cortés-Mendoza, Javier, Herrera-Ruiz, Maribel, Jiménez-Ferrer, Enrique, Zamilpa, Alejandro, Tortoriello, Jaime, Pedraza-Alva, Gustavo, Pérez-Martínez, Leonor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617588/
https://www.ncbi.nlm.nih.gov/pubmed/31291963
http://dx.doi.org/10.1186/s12974-019-1515-3